对于Pd(II)催化领域,选择性进行亚甲基C-H键官能团化具有非常大的挑战。
有鉴于此,普林斯顿大学Erik J. Sorensen等报道Pd(II)催化,实现了对酮选择性进行亚甲基C(sp3)-H键芳基化,构建苯并环丁烯。
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参考文献
Philip A. Provencher, John F. Hoskin, Jonathan J. Wong, Xiangyang Chen, Jin-Quan Yu, K. N. Houk, and Erik J. Sorensen*, Pd(II)-Catalyzed Synthesis of Benzocyclobutenes by β-Methylene-Selective C(sp3)–H Arylation with a Transient Directing Group, J. Am. Chem. Soc. 2021
DOI: 10.1021/jacs.1c09368
https://pubs.acs.org/doi/10.1021/jacs.1c09368