西南大学官智、何延红、广西师范学院黄初升等报道将脂肪酶的非天然催化活性与电催化结合,将二级有机胺和酮的立体选择性交叉偶联反应,反应从2-位点修饰的吲哚合成了多种多样的含有立体结构四级碳原子位点的2,2,-双官能团取代3-羰基吲哚,产率达到78 %,立体选择性和对映选择性达到96:4 er、>20:1 d.r.。
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参考文献
Chao-Jiu Long, Huan Cao, Ben-Kun Zhao, Yu-Fang Tan, Yan-Hong He, Chu-Sheng Huang, Zhi Guan, Merging the Non-Natural Catalytic Activity of Lipase and Electrosynthesis: Asymmetric Oxidative Cross-Coupling of Secondary Amines with Ketones, Angew. Chem. Int. Ed. 2022
DOI: 10.1002/anie.202203666
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202203666