Jang等人通过将ZIF-8和微孔有机网络（MON）材料交替引入到单壳层空心 MON中制备了磺化微孔有机网络(TH-SMON和DHSMON)的三壳层空心球和双壳层空心球。随着壳体数量的增加，中空球体不仅由于与药物的有效接触而呈现出较高的DOX负载量；而且由于增强了水溶性，在细胞水平也表现出较高的药物释放量。

Jang, J.Y., Le, T.M.D. et al. Triple, Double, and Single Shelled Hollow Spheres of Sulfonated Microporous Organic Network as Drug Delivery Materials.

Chemistry of Materials

DOI: 10.1021/acs.chemmater.8b04674

https://pubs.acs.org/doi/10.1021/acs.chemmater.8b04674